Biomimetic Sequence-Templating Approach toward a Multiscale Modulation of Chromogenic Polymer Properties

• DOI: 10.1021/acs.macromol.3c00403
• Publication Date: 2023-06-15T18:02:20Z
• Authors: Yuyao Kuang; Ze-Fan Yao; Sujeung Lim; Catherine Ngo; Megan Alma Rocha; Dmitry A. Fishman; Herdeline Ann M. ...
• Keywords: Diacetylene; Sequence (biology)

Precision control via molecular structure over adaptive conjugated polymer properties in aqueous environments is critical for realizing their biomedical applications. Here, we unravel the dependence of amphiphilic peptide-polydiacetylene (PDA) conjugate on characteristic steric and hydrophobic contributions within peptide segments that serve as a biomimetic template diacetylene polymerization water. We investigated functional impacts volume polarity changes brought by dipeptide substitution domains following peptide-PDA material at multiple length scales: supramolecular assembly behavior, chain conformation-dependent photophysical properties, cell-material interfacing, first time, bulk electrical films processed A library peptide-PDAs with systematically varied sequences show effects predominantly influence electronic resulting trends while interplay between size hydrophobicity individual residues becomes more significant higher-order assemblies affecting properties. This work demonstrates sequence-tunable synthetic handles to rationally modulate PDA across scales, providing insights into programmability polymers functionalities.