Correlated Fluctuations of DNA between Nanofluidic Entropic Traps

• DOI: 10.1021/acs.macromol.5b00961
• Publication Date: 2015-06-19T18:36:31Z
• Authors: Alexander R. Klotz; Mikhail Mamaev; Lyndon Duong; Hendrick W. de Haan; Walter W. Reisner
• Keywords: Antisymmetric relation; Langevin equation; Oscillation (cell signaling); Harmonic; Langevin dynamics

Here we explore thermally driven contour fluctuations within a single DNA chain partitioned between two embedded cavity reservoirs in nanofluidic slit. Analysis of integrated intensity suggests that is exchanged dynamically the via modes resemble symmetric and antisymmetric coupled harmonic oscillator. The relaxation time measured as function width spacing. Langevin dynamics simulations reproduce our observations motivate free energy model with blob-type hydrodynamic friction, developed used to deduce how times for depend on device parameters. mode was found be consistent an excluded volume-based stiffness while faster depends additional entropic elastic