Tricomponent Amphiphilic Poly(oligo(ethylene glycol) methacrylate) Brush-Grafted Poly(lactic acid): Synthesis, Nanoparticle Formation, and In Vitro Uptake and Release of Hydrophobic Dyes

• DOI: 10.1021/acs.macromol.9b02467
• Publication Date: 2020-05-15T21:54:19Z
• Authors: Pranav P. Kalelkar; David M. Collard
• Keywords: Atom-transfer radical-polymerization; Macromonomer

Tricomponent amphiphilic brush-grafted copolymers of poly(lactic acid)-graft-poly(oligo(ethylene glycol) methacrylate) (PLA-g-POEGMA) were prepared by atom-transfer radical polymerization (ATRP) oligo(ethylene methacrylate (OEGMA) macromer using brominated acid) (Br-PLA) as a multisite macroinitiator. Br-PLA was free bromination (PLA) with N-bromosuccinimide (NBS). The copolymer, PLA-g-POEGMA, self-assembled to form sub-100 nm nanoparticles in aqueous solution. We report the uptake and release hydrophobic dyes buffer presence serum proteins low toxicity toward mammalian cells.