Synergistic Chemotherapy for Breast Cancer and Breast Cancer Brain Metastases via Paclitaxel-Loaded Oleanolic Acid Nanoparticles

• DOI: 10.1021/acs.molpharmaceut.0c00044
• Publication Date: 2020-03-09T20:52:26Z
• Authors: Youmei Bao; Shenqi Zhang; Zeming Chen; Ann T. Chen; Junning Ma; Gang Deng; Weiguo Xu; Jiangbing Zhou; Zhi-Qiang Yu; Guangyu Yao; Jianjun Chen
• Keywords: Regimen

Breast cancer is the most common type of in women. About 12% all women United States will be diagnosed with breast over their lifetimes. At same time, incidences brain metastases (BMs) are increasing and represent an emerging health threat. However, there no effective chemotherapy for (BCBMs), which largely due to lack efficient delivery antitumor drugs or drug combinations brain. In this study, oleanolic acid (OA), a natural pentacyclic triterpenoid compound excellent activity, was found form nanoparticles (NPs) efficiently penetrate BCBMs treatment. On basis these findings, we developed synergistic combinatorial chemotherapeutic regimen by formulating paclitaxel (PTX) into OA NPs demonstrated that resulting PTX-OA effectively inhibited primary mouse xenografts. Collectively, study introduces new direction treat through noninvasive combination chemotherapy.