Drug Loading in Poly(butyl cyanoacrylate)-Based Polymeric Microbubbles

• DOI: 10.1021/acs.molpharmaceut.0c00242
• Publication Date: 2020-06-27T05:44:27Z
• Authors: Mengjiao Liu; Anshuman Dasgupta; Patrick Koczera; Sandra Schipper; Dirk Rommel; Yang Shi; Fabian Kiessling; Twan Lammers
• Keywords: 0301 basic medicine; Microbubbles; Polymers; Chemistry, Pharmaceutical; Enbucrilate; 3. Good health; Molecular Weight; 03 medical and health sciences; Drug Delivery Systems; Pharmaceutical Preparations; Nanoparticles; Hydrophobic and Hydrophilic Interactions; Fluorescent Dyes

Microbubbles (MB) are routinely used ultrasound (US) contrast agents that have recently attracted increasing attention as stimuli-responsive drug delivery systems. To better understand MB-based delivery, we studied the role of hydrophobicity and molecular weight on MB loading, shelf-life stability, US properties, release. Eight model drugs, varying in weight, were loaded into shell poly(butyl cyanoacrylate) (PBCA) MB. In case drugs with progesterone a common structural backbone (i.e., for corticosteroids), loading capacity release correlated well weight. Conversely, when employing no similarity four different fluorescent dyes), did not correlate All drug-loaded formulations could be equally efficiently destroyed upon exposure to US. Together, these findings provide valuable insights how physicochemical properties (model) molecules affect their retention US-induced from polymeric MB, thereby facilitating development US-triggered delivery.