Insights into the Impact of Nanostructural Properties on Powder Tribocharging: The Case of Milled Salbutamol Sulfate

• DOI: 10.1021/acs.molpharmaceut.1c00668
• Publication Date: 2022-01-19T16:10:54Z
• Authors: Michela Beretta; Joana T. Pinto; Peter Laggner; Amrit Paudel
• Keywords: Particle (ecology)

The impact of the crystallinity organic solid materials on their tribocharging propensity is well reported. However, no unequivocal explanation about potential underlying mechanism(s) could be found so far in literature. This study reports effect that different degrees crystalline disorder has a small molecular material, salbutamol sulfate (SS). Ball-milling was used to induce structural transformations structure SS. Particles with nanostructures were produced and analyzed for solid-state, particle properties, tribocharging. It differences amorphous content among processed particles related moisture levels had an powder A correlation between latter nanostructural properties also established. presence interfaces nanodomains densities shorter average lengths within phases seems lead mitigation charge. suggests undetected, subtle can affect handling processability by altering present findings demonstrate implications triboelectrification, which help toward rational design wide variety solids.