Comparative Study of Latanoprost Drug Delivery Systems for Glaucoma Treatment and Their Interaction with the Tear Film Lipid Layer Models

• DOI: 10.1021/acs.molpharmaceut.3c00635
• Publication Date: 2023-12-19T03:44:01Z
• Authors: Maria Chiara Saija; Katarina Vazdar; Wojciech Pajerski; Agnieszka Olżyńska; Philippe Daull; Jean-Sebastien Ga...; Lukasz Cwiklik
• Keywords: Benzalkonium chloride

This study investigates the interaction of two approved and one newly developed latanoprost formulation with in vitro silico models tear film lipid layer (TFLL). Latanoprost, a prostaglandin analogue used for intraocular elevated pressure treatment, is topically delivered by nanocarriers within aqueous solutions or emulsions. The focuses on impact these carriers drug interactions their effect TFLL. Three different types carriers, micellar, nanoemulsion, polymer-based, were compared, each revealed distinct patterns Surface kinetics demonstrated rapid increase benzalkonium chloride slow rise preservative-free variants. Visualization acellular TFLL model incorporation formulation, indicating unique mechanisms. Molecular dynamics simulations further mechanisms release between micellar nanoemulsion formulations. In-depth examination highlighted role triglyceride molecules replenishing nonpolar TFLL, which suggests potential improvements ocular surface compatibility adjusting quality concentration oily phase. These findings suggest optimizing formulations tuning phase-to-surfactant ratio selecting suitable surfactants.