Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2′,3,3′-Tetrabromo-4,4′,5,5′-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice

• DOI: 10.1021/acs.molpharmaceut.8b01106
• Publication Date: 2019-04-12T02:04:04Z
• Authors: Chao Li; Jiao Luo; Shuju Guo; Xiaoling Jia; Chuanlong Guo; Xiangqian Li; Qi Xu; Dayong Shi
• Keywords: Male; 0301 basic medicine; Plant Extracts; Administration, Oral; Hydrogen Bonding; Cell Line; 3. Good health; Mice, Inbred C57BL; Molecular Docking Simulation; Myoblasts; Mice; Inhibitory Concentration 50; 03 medical and health sciences; Diabetes Mellitus, Type 2; Liver; Mice, Inbred NOD; Catalytic Domain; Animals; Hypoglycemic Agents; Insulin; Benzhydryl Compounds; Insulin Resistance; Glycogen

Protein tyrosine phosphatase 1B (PTP1B) is a widely confirmed target of the type 2 diabetes mellitus (T2DM) treatment. Herein, we reported highly specific PTP1B inhibitor 2,2',3,3'-tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane (compound 1), which showed promising hypoglycemic activity in diabetic BKS db mice. With IC