Combined Cancer Chemo-Photodynamic and Photothermal Therapy Based on ICG/PDA/TPZ-Loaded Nanoparticles

• DOI: 10.1021/acs.molpharmaceut.9b00119
• Publication Date: 2019-04-12T18:46:51Z
• Authors: Xiaqin Huang; Junru Wu; Muye He; Xinyu Hou; Yan Wang; Xiaoran Cai; Hongliang Xin; Feng Gao; Yanzuo Chen
• Keywords: Tirapazamine; Indocyanine Green; Tumor Hypoxia

Although photodynamic therapy (PDT) has been an attractive strategy for several cancer treatments in the clinical setting, PDT efficacy is attenuated by consumption of oxygen. To address this issue, we adopted a phototherapy-chemotherapy combination based on targeted delivery near-infrared photosensitizer indocyanine green (ICG), photothermal conversion agent polydopamine (PDA), and tirapazamine (TPZ), hypoxia-activated prodrug. Under laser irradiation, ICG oxygen aggravated hypoxia tumor sites can activate TPZ to damage DNA. In parallel, produces reactive species which work synergy with PDA enhance phototherapeutic efficiency. Herein, hybrid CaCO