De Novo Design of Cu(II) Complex Containing CNC–Pincer–Vitamin B3 and B7 Conjugates for Breast Cancer Application

• DOI: 10.1021/acs.molpharmaceut.9b00399
• Publication Date: 2019-07-22T19:14:50Z
• Authors: Leila Tabrizi; Fatemeh Abyar
• Keywords: Conjugate

A Cu(II) complex, that is, [Cu(CNC-B3)(IM-B7)](PF6)2, 1, containing CNC-B3 (L2) = CNC–pincer–vitamin B3 and IM-B7 (L3) 1H-imidazole-1-methanamine-vitamin B7 conjugates, was developed as a potential chemotherapeutic agent for breast cancer cell lines. The complex brings about remarkable in vitro cytotoxicity comparison with cisplatin tamoxifen against MDA-MB-231 MCF-7 Interestingly, the considerably less toxic to MRC-5 normal cells. DNA/human serum albumin-binding capacity of confirmed by spectrometric methods molecular docking ONIOM studies. mechanistic pathway DNA cleavage studied reactive oxygen species (ROS)-inhibiting agents. Furthermore, affected increasing level (ROS) decreasing glutathione new induced major levels death apoptosis.