A Robust Oxygen-Carrying Hemoglobin-Based Natural Sonosensitizer for Sonodynamic Cancer Therapy

• DOI: 10.1021/acs.nanolett.1c01220
• Publication Date: 2021-07-13T14:40:05Z
• Authors: Meng Yuan; Shuang Liang; Ying Zhou; Xiao Xiao; Bin Liu; Chunzheng Yang; Ping’an Ma; Ziyong Cheng; Jun Lin
• Keywords: Sonodynamic therapy; Biocompatibility; Imidazolate

The development of novel sonosensitizers with outstanding reactive oxygen (ROS) generation capacity and great biocompatibility poses a significant challenge for the clinical practice sonodynamic therapy (SDT). In this work, hemoglobin (Hb) natural metalloporphyrin was first shown to possess potential as sonosensitizer. Compared traditional organic sonosensitizers, Hb had satisfactory sono-sensitizing efficiency because four porphyrin molecules were separated by polypeptide chains. This effectively avoided problem low ROS quantum yield caused stacking hydrophobic porphyrins. Meanwhile, is an efficient safe carrier that may release O2 at hypoxic tumors site, which improved tumor oxygenation subsequently enhanced SDT efficacy. Therefore, integrated zeolitic imidazolate framework 8 (ZIF-8) form nanoplatform demonstrated potent suppression effect on deep-seated under ultrasound irradiation.