Intelligent Pore Switch of Hollow Mesoporous Organosilica Nanoparticles for High Contrast Magnetic Resonance Imaging and Tumor-Specific Chemotherapy

• DOI: 10.1021/acs.nanolett.1c03130
• Publication Date: 2021-11-05T14:16:19Z
• Authors: Lin Huang; Jie Feng; Wenpei Fan; Wei Tang; Xiaoxiang Rong; Wangjun Liao; Zhenni Wei; Yikai Xu; Aiguo Wu; Xiaoyuan Chen; Zheyu Shen
• Keywords: Nanocarriers; Mesoporous organosilica

Hollow mesoporous organosilica nanoparticles (HMONs) are widely considered as a promising drug nanocarrier, but the loaded drugs can easily leak from HMONs, resulting in considerably decreased loading capacity and increased biosafety risk. This study reports smart use of core/shell Fe3O4/Gd2O3 (FG) hybrid gatekeeper to block pores which yield an unreported large content (up 20.4%) DOX. The conjugation RGD dimer (R2) onto DOX-loaded HMON with FG capping (D@HMON@FG@R2) allowed for active tumor-targeted delivery. aggregated D@HMON@FG@R2 could darken normal tissue surrounding tumor due high r2 value (253.7 mM-1 s-1) r2/r1 ratio (19.13), intratumorally released result reducibility-triggered degradation brighten because r1 (20.1 low (7.01), contributed contrast magnetic resonance imaging (MRI) guiding highly efficient tumor-specific DOX release chemotherapy.