Pulmonary Delivery of Theranostic Nanoclusters for Lung Cancer Ferroptosis with Enhanced Chemodynamic/Radiation Synergistic Therapy

• DOI: 10.1021/acs.nanolett.1c03786
• Publication Date: 2022-01-25T03:48:41Z
• Authors: Yingbo Li; Jie Yang; Guangying Gu; Xu Guo; Chunbo He; Jiemei Sun; Hongyan Zou; Hongbin Wang; Shuang Liu; Xiaona Li; Shujun Zhang; Kai Wang; Lili Yang; Ying Jiang; Lina Wu; Xilin Sun
• Keywords: Nanoclusters

Inefficient tumor accumulation and penetration remain as the main challenges to therapy efficacy of lung cancer. Local delivery smart nanoclusters can increase drug provide superior antitumor effects than systemic routes. Here, we report self-assembled pH-sensitive superparamagnetic iron oxide (SPIONCs) that enhance in situ ferroptosis apoptosis with radiotherapy chemodynamic therapy. After pulmonary orthotopic cancer, SPIONCs disintegrate into smaller nanoparticles release more ions an acidic microenvironment. Under single-dose X-ray irradiation, endogenous superoxide dismutase converts radicals produced by mitochondria hydrogen peroxide, which turn generates hydroxyl Fenton reaction from accumulated inside tumor. Finally, irradiation lipid peroxidation induce cell ferroptosis. Thus, rationally designed delivered a promising strategy for noninvasive imaging cancer synergistic