Label-Free Spectroscopic SARS-CoV-2 Detection on Versatile Nanoimprinted Substrates

• DOI: 10.1021/acs.nanolett.1c04722
• Publication Date: 2022-03-29T15:31:46Z
• Authors: Debadrita Paria; Kam Sang Kwok; Piyush Raj; Peng Zheng; David H. Gracias; Ishan Barman
• Keywords: Surface-Enhanced Raman Spectroscopy; Wearable Technology

Widespread testing and isolation of infected patients is a cornerstone viral outbreak management, as underscored during the ongoing COVID-19 pandemic. Here, we report large-area label-free platform that combines surface-enhanced Raman spectroscopy machine learning for rapid accurate detection SARS-CoV-2. Spectroscopic signatures acquired from virus samples on metal–insulator–metal nanostructures, fabricated using nanoimprint lithography transfer printing, can provide test results within 25 min. Not only our technique accurately distinguish between different respiratory nonrespiratory viruses, but it also detect in physiologically relevant matrices such human saliva without any additional sample preparation. Furthermore, large area nanopatterning approach allows sensors to be flexible surfaces allowing them mounted surface or used wearables. We envision versatile portable spectroscopic will offer an important tool future preparedness.