Black Phosphorus Flake-Enabled Wireless Neuromodulation for Epilepsy Treatment

• DOI: 10.1021/acs.nanolett.3c03472
• Publication Date: 2023-11-13T12:16:32Z
• Authors: Deqi Yang; Qinjuan Ren; Jianfang Nie; Ya Zhang; Haofan Wu; Zhiqiang Chang; Bingfang Wang; Jing Dai; Yin Fang
• Keywords: Neuromodulation; Black Phosphorus; Nanomaterials

Epilepsy is a prevalent and severe neurological disorder generally requires prolonged electrode implantation tether brain stimulation in refractory cases. However, implants may cause potential chronic immune inflammation permanent tissue damage due to material property mismatches with soft tissue. Here, we demonstrated nanomaterial-enabled near-infrared (NIR) neuromodulation approach provide nongenetic nonimplantable therapeutic benefits epilepsy mouse models. Our study showed that crystal-exfoliated photothermal black phosphorus (BP) flakes could enhance neural activity by altering the membrane capacitive currents hippocampus neurons through NIR neuromodulation. Optical facilitated BP hippocampal slices evoked action potentials high spatiotemporal resolution. Furthermore, flake-enabled of circuits can suppress epileptic signals model mice minimal invasiveness biocompatibility. Consequently, open up opportunities for optical therapy nontransgenic organisms.