Confined-Enhanced Raman Spectroscopy

• DOI: 10.1021/acs.nanolett.3c03734
• Publication Date: 2023-12-13T17:15:52Z
• Authors: Ruiyuan Zhang; Lingwei Li; Yu Guo; Yafei Shi; Jian-Feng Li; Yi-Tao Long; Jixiang Fang
• Keywords: Nanoshell; Surface-Enhanced Raman Spectroscopy

In 1997, the discovery of single molecule–surface enhanced Raman spectroscopy (SM-SERS) rekindled broad interests owing to its ultrahigh enhancement factor up 1014–1015 level. However, regretfully, advantage SM-SERS with an ultralow detection limit has not yet been fully utilized in commercialized applications. Here, we report a strategy, which name confined-enhanced spectroscopy, overall properties can be remarkably improved situ-formed active nanoshell on surface silver or gold nanoparticles. The confine and anchor molecules onto plasmonic nanoparticles avoid desorption from hot spots so that "on off" blinking effect eliminated. It is first time single-molecule analytes super sensitivity, high stability, reproducibility based realized. addition, this strategy suitable for SERS diverse molecule systems, including biomedical diagnosis, catalytic reaction, etc.