Scalable Drug-Mimicking Nanoplasmonic Therapy for Bradyarrhythmia in Cardiomyocytes

• DOI: 10.1021/acs.nanolett.4c03213
• Publication Date: 2024-08-30T20:57:17Z
• Authors: Dongxin Xu; Xuelian Lyu; Haote Han; Jiaru Fang; Jiajin Xue; Jilin Zheng; Ning Hu; Zhigang Gao
• Keywords: Nanorod

Bradyarrhythmia poses a serious threat to human health, with chronic progression causing heart failure and acute onset leading sudden death. In this study, we develop scalable drug-mimicking nanoplasmonic therapeutic strategy by introducing gold nanorod (Au NR) mediated near-infrared (NIR) photothermal effects. An integrated sensing regulation platform is established for in situ synchronized NIR laser electrophysiological property recording. The Au NR plasmonic enables the restoration of normal cardiomyocyte rhythm from bradyarrhythmia. By regulating aspect ratio concentration NRs, as well intensity time irradiation, precisely optimized effect explore effective strategies. Furthermore, mRNA sequencing revealed significant increase number differentially expressed genes (DEGs) involved activities cardiomyocytes following therapy. NR-mediated therapy, an efficient noninvasive approach bradyarrhythmia, holds profound implications cardiology research.