Phototriggered Local Anesthesia

• DOI: 10.1021/acs.nanolett.5b03440
• Publication Date: 2015-12-14T18:53:01Z
• Authors: Changyou Zhan; Weiping Wang; James B. McAlvin; Shutao Guo; Brian P. Timko; Claudia Santamaria; Daniel S. Kohane
• Keywords: Dexmedetomidine; Tetrodotoxin; Sodium channel blocker

We report a phototriggerable formulation enabling in vivo repeated and on-demand anesthesia with minimal toxicity. Gold nanorods (GNRs) that can convert near-infrared (NIR) light into heat were attached to liposomes (Lip-GNRs), light-triggered phase transition of their lipid bilayers consequent release payload. Lip-GNRs containing the site 1 sodium channel blocker tetrodotoxin α2-adrenergic agonist dexmedetomidine (Lip-GNR-TD) injected subcutaneously rat footpad. Irradiation an 808 nm continuous wave NIR laser produced infiltration footpad proportion irradiance, The ability achieve local could be very beneficial management pain.