Transcytosis of Nanomedicine for Tumor Penetration

• DOI: 10.1021/acs.nanolett.9b03211
• Publication Date: 2019-10-23T18:35:26Z
• Authors: Yan Liu; Yingying Huo; Lin Yao; Yawen Xu; Fanqiang Meng; Haifeng Li; Kang Sun; Guangdong Zhou; Daniel S. Kohane; Ke Tao
• Keywords: Transcytosis; Penetration (warfare); Nanocarriers

The diffusion of nanomedicines used to treat tumors is severely hindered by the microenvironment, which a challenge that has emerged as bottleneck for effective outcome nanotherapies. Classical strategies enhancing tumor penetration rely on passive movement in extracellular matrix (ECM). Here, we demonstrate nanomedicine also penetrates lesions via an active trans-cell transportation process. This process was discovered directly observing nanoparticles between cells, evaluating intracellular trafficking pathway Rab protein labeling, comparing endocytosis-exocytosis administered with inhibitors, and correlating transcytosis micro-CT distribution nanomedicines. We demonstrated enhanced promotes therapeutic efficacy photodynamic nanomedicine. Our research thus suggests could be important positive factor designing cancer