Development and Scale-Up of an Improved Manufacturing Route to the ATR Inhibitor Ceralasertib

• DOI: 10.1021/acs.oprd.0c00482
• Publication Date: 2020-12-15T18:18:56Z
• Authors: Mark A. Graham; Hannah Askey; Andrew D. Campbell; Lai Chan; Katie G. Cooper; Zhaoshan Cui; Andrew Dalgleish; David Dave; Gareth Ensor; Maria Rita Galan ...; Peter Hamilton; Claire Heffernan; Lucinda V. Jackson; Dajiang Jing; Martin F. Jones; Pengpeng Liu; Keith R. Mulholland; Mohammed Pervez; Michael Popadynec; Emma Randles; Simone Tomasi; Shenghua Wang
• Keywords: 01 natural sciences; 0104 chemical sciences; 3. Good health

Ceralasertib is currently being evaluated in multiple phase I/II clinical trials for the treatment of cancer. Its structure, comprising a pyrimidine core decorated with a chiral morpholine, a cyclo...