Scalable Quasi-Divided Cell Operation Using Spinning Cylinder Electrode Technology: Multigram Electrochemical Synthesis of an Axitinib Intermediate

• DOI: 10.1021/acs.oprd.3c00508
• Publication Date: 2024-02-28T08:46:11Z
• Authors: Bhanwar K. Malviya; Eric C. Hansen; Caleb J. Kong; Joseph Imbrogno; Jenson Verghese; Steven M. Guinness; Chase A. Salazar; Jean-Nicolas Desr...; C. Oliver Kappe; David Cantillo
• Keywords: Axitinib; Electrochemical cell

Electrochemical synthesis of a key thiol intermediate in the preparation axitinib has been achieved on multi-10 g scale using modified spinning cylinder electrode reactor adapted for "quasi-divided" cell operation. This concept enables target cathodic reduction to occur without need sacrificial electrodes or divided cells equipped with ion exchange membranes. The new design, based scalable platform, features an inner cathode made leaded bronze and vessel which variable number counter-electrode rods can be attached. setup permits high flexibility cathode/anode surface area ratio required shown provide excellent yields batch flow recirculation modes. Continuous operation cascade three reactors was also demonstrated.