Coordination Behavior of Acylthiourea Ligands in Their Ru(II)–Benzene Complexes─Structures and Anticancer Activity

• DOI: 10.1021/acs.organomet.2c00127
• Publication Date: 2022-06-25T12:54:45Z
• Authors: Srividya Swaminathan; Jebiti Haribabu; Mohamed Kasim Moh...; Gunasekaran Manon...; Kittusamy Senthil...; Nithya Balakrishnan; Nattamai Bhuvanesh; Cesar Echeverria; Ramasamy Karvembu
• Keywords: Coordination complex

Acylthiourea ligands have applications in both synthetic and applied chemistry. The skeleton of the ligand contains several heteroatoms which offer variable coordination modes their complexes. Herein, we report one such erratic behavior these types complexes upon crystallization. Six Ru(II)–benzene (B1–B6) containing acylthiourea were synthesized adequately characterized using analytical spectroscopic techniques. In contrast to data confirming monodentate Ru(II) ion, bidentate version crystal structure was observed. To best our knowledge, this is only as now on N,S-coordinated forming a four-membered ring complexes, while same Ru(II)–p-cymene system showed coordination. exhibited good anticancer potential A549, overcame cisplatin resistance cisRA549, but unfortunately toxicity toward normal human umbilical vein endothelial cell lines. An increase chain length at C-terminal conjugation N-terminal seemed improve cytotoxic profile 5-Ethynyl-2′-deoxyuridine staining helped visualize interruption DNA synthesis by active B4 B5, further authenticated flow cytometry, wherein arrested cycle S phase. latter also proved apoptosis mode death induced morphological changes due visualized acridine orange/ethidium bromide staining.