Ruthenium-Catalyzed Cross-Selective Asymmetric Oxidative Coupling of Arenols

• DOI: 10.1021/acs.orglett.0c00048
• Publication Date: 2020-01-27T12:17:40Z
• Authors: Hiroki Hayashi; Takamasa Ueno; Chungsik Kim; Tatsuya Uchida
• Keywords: Electronic effect

(Aqua)ruthenium(salen) complex 1c achieved good to high chemo- and enantioselective oxidative cross-coupling of arenols. The catalytic system can be used selectively produce C1-symmetric bis(arenol)s from the combination C3- C7-substituted 2-naphthols or phenols even when there is no significant difference in oxidation potential between partners. This unique cross-selectivity dominated by steric rather than electronic effects arenols controlled chemoselective single-electron carbon-carbon bond formation.