Wheldone: Characterization of a Unique Scaffold from the Coculture of Aspergillus fischeri and Xylaria flabelliformis

• DOI: 10.1021/acs.orglett.0c00219
• Publication Date: 2020-02-25T14:07:41Z
• Authors: Sonja L. Knowles; Huzefa A. Raja; Israa H. Isawi; Laura Flores-Boca...; Patricia H. Reggio; Cedric J. Pearce; Joanna E. Burdette; Antonis Rokas; Nicholas H. Oberlies
• Keywords: Cancer cell lines

Wheldone (1) was isolated and elucidated from a coculture of Aspergillus fischeri (NRRL 181) Xylaria flabelliformis (G536), where secondary metabolite biosynthesis stimulated by antagonism between these fungi. First observed via in situ analysis competing fungal cultures, the conditions were scaled to reproducibly generate 1, whose novel structure one- two-dimensional NMR mass spectrometry. Compound 1 displayed cytotoxic activity against breast, ovarian, melanoma cancer cell lines.