Rhodium(III)-Catalyzed Cyclopropane C–H/C–C Activation Sequence Provides Diastereoselective Access to α-Alkoxylated γ-Lactams

• DOI: 10.1021/acs.orglett.0c01606
• Publication Date: 2020-06-17T14:36:23Z
• Authors: Benoit Audic; Nicolai Cramer
• Keywords: Cyclopropane; Sequence (biology)

A Cp*Rh(III)-catalyzed C–H/C–C bond activation sequence of cyclopropyl hydroxamates has been developed. The three-component process allows trapping the intermediate rhodacycle with diazomalonates and an alcohol nucleophile to provide access synthetically valuable α-alkoxylated γ-lactams trans diastereoselectivity.