Copper-Catalyzed Direct C(sp3)–H Alkoxylation to Access Quaternary α-Alkoxylated Amino Acid Derivatives

• DOI: 10.1021/acs.orglett.0c01853
• Publication Date: 2020-07-14T20:43:21Z
• Authors: Qiang Wei; Yao Ma; Yi Dong; Gang Liu
• Keywords: Amide; Peptide bond; Functional group

A copper-catalyzed C(sp3)–H alkoxylation was developed to prepare quaternary α-alkoxylated amino acid derivatives in good yields. This protocol can be applied a series of α-amino acids bearing variety functional group substituents. Facile removal the auxiliary directing and tolerance condensation conditions for amide bond formation enable potential application this method discovery new peptide drugs future.