Organo-photoredox-Catalyzed Atom-Transfer Radical Substitution of Alkenes with α-Carbonyl Alkyl Halides

• DOI: 10.1021/acs.orglett.0c03359
• Publication Date: 2020-11-04T16:11:56Z
• Authors: Goki Hirata; Taisei Shimada; Takashi Nishikata
• Keywords: Photoredox catalysis; Functional group

A light-driven atom-transfer radical substitution (ATRS) and carboesterification reaction of alkenes with alkyl halides has been developed using PTH as the organo-photoredox catalyst. Two types products were obtained, depending on additive solvent used during reaction. Primary, secondary, tertiary reacted to give ATRS products. This protocol several advantages: it requires mild conditions a low catalyst loading exhibits broad substrate scope good functional group tolerance. Mechanistic studies indicate that radicals might be generated key intermediates via photocatalysis, providing new direction for reactions.