Pchaeglobolactone A, Spiropchaeglobosin A, and Pchaeglobosals A and B: Four Rearranged Cytochalasans from Chaetomium globosum P2-2-2

• DOI: 10.1021/acs.orglett.0c03623
• Publication Date: 2020-12-03T17:27:21Z
• Authors: Xiao-Gang Peng; Junjun Liu; Ying Gao; Fang Cheng; Jin-Ling Chang; Juan Chen; Fang-Fang Duan; Han-Li Ruan
• Keywords: 0301 basic medicine; 03 medical and health sciences; Molecular Structure; Biochemical Phenomena; Antineoplastic Agents; Apoptosis; Chaetomium; Drug Screening Assays, Antitumor; Cytochalasins; 3. Good health

Four novel rearranged cytochalasans (1-4) were isolated from an endophytic fungus Chaetomium globosum P2-2-2. Pchaeglobolactone A (1) possessed an unprecedented 13-aza-21-oxa-tetracyclo-[10.6.1.217,19.015,19]henicosane core. Spiropchaeglobosin A (2) was the first example of cytochalasans featuring a novel spiro[5.10]hexadecane unit. Pchaeglobosals A (3) and B (4) featured a unique 5/5/13 fused tricyclic ring system. Compounds 1-4 were tested for their antiproliferative, apoptosis, cell cycle arrest, and TRAIL-resistance-overcoming activities on cancer cell lines.