Aryl(TMP)iodonium Tosylate Reagents as a Strategic Entry Point to Diverse Aryl Intermediates: Selective Access to Arynes

• DOI: 10.1021/acs.orglett.1c01534
• Publication Date: 2021-05-25T16:12:04Z
• Authors: Aleksandra Nilova; Bryan Metze; David R. Stuart
• Keywords: Aryne; Chemical space

Arenes are broadly found motifs in societally important molecules. Access to diverse arene chemical space is critically important, and the ability do so from common reagents highly desirable. Aryl(TMP)iodonium tosylates provide one such access point via aryl intermediates. Here we demonstrate that controlling reaction pathways selectively leads arynes with a broad scope of arenes arynophiles (24 examples, 70% average yield) efficient biologically active compounds.