Nickel-Catalyzed Diastereoselective Reductive Cross-Coupling of Disubstituted Cycloalkyl Iodides with Aryl Iodides

• DOI: 10.1021/acs.orglett.1c01649
• Publication Date: 2021-06-23T13:45:30Z
• Authors: Xuan-Di Song; Meng-Meng Guo; Shuang Xu; Chuanji Shen; Xiaocong Zhou; Xue-Qiang Chu; Mengtao Ma; Zhi-Liang Shen
• Keywords: Reductive elimination; Coupling reaction; Functional group

A nickel-catalyzed direct reductive cross-coupling of disubstituted cycloalkyl iodides with aryl was developed. The one-pot reaction, which is simple to operate, capable proceeding efficiently in a stereocontrolled manner afford variety cross-coupled products high diastereoselectivity and wide functional group tolerance.