Direct C–C Bond Cleavage of 1,3-Dicarbonyl Compounds as a Single-Carbon Synthon: Synthesis of 2-Aryl-4-quinolinecarboxylates

• DOI: 10.1021/acs.orglett.1c02267
• Publication Date: 2021-08-04T16:07:39Z
• Authors: You Zhou; Peng Zhao; Li-Sheng Wang; Xiao-Xiao Yu; Chun Huang; Yan-Dong Wu; An-Xin Wu
• Keywords: Synthon; Bond cleavage; Cleavage (geology)

A novel [2 + 1 3] cyclization reaction for the synthesis of 2-aryl-4-quinolinecarboxylates from aryl methyl ketones, arylamines, and 1,3-dicarbonyl compounds has been established. This metal-free process achieved C–C bond cleavage directly as a single-carbon synthon. The is highly efficient good substrate compatibility while operating under mild conditions. method practicability successfully realized bioactive molecules.