Visible-Light-Driven Bisfunctionalization of Unactivated Olefins via the Merger of Proton-Coupled Electron Transfer and Carbene Catalysis

• DOI: 10.1021/acs.orglett.1c03941
• Publication Date: 2021-12-21T17:46:56Z
• Authors: Bei Zhang; Jian-Qing Qi; Yuhan Liu; Zhipeng Li; Jian Wang
• Keywords: Synthon

Herein, we reported an N-heterocyclic carbene (NHC) and photo-co-catalyzed alkylacylation of olefins in the presence versatile synthon diazo ester, providing a new idea for transient radical generation with only byproduct being N2. Particularly, this process employs traditional precursor esters as source, which is first case NHC catalysis. Compared to previous pathway that produces radicals large discard fragments, merged channel possesses great atom economy.