Aspergichromones A–E, Five Chromone Derivatives with Complicated Polycyclic Architecture from Aspergillus deflectus

• DOI: 10.1021/acs.orglett.2c00113
• Publication Date: 2022-02-18T13:20:26Z
• Authors: Xin Liu; Yan Fu; Qiqi Zhou; Su Wang; Lu Gao; Jiali Lei; Aibing Ke; Yeying Li; Xuexia Zhang; Changhong Huo; Xinhua Lu
• Keywords: Chromone

Five unprecedented chromone derivatives involving a 6/6/5/5/5/6 hexacyclic scaffold (1, 2), 6/6/5/6/6/6/6 heptacyclic (3), and 6/6/6/5/5/6 (4, 5) were obtained from the fungus Aspergillus deflectus NCC0415. Their structures identified using comprehensive spectroscopic analysis, single-crystal X-ray diffraction, electronic circular dichroism calculations. Except for 3, other compounds, especially (4 5), exhibited potent inosine-5′-monophosphate dehydrogenase (IMPDH) inhibitory activities.