Rhodium(III)-Catalyzed Atroposelective Synthesis of C–N Axially Chiral Naphthylamines and Variants via C–H Activation

• DOI: 10.1021/acs.orglett.2c00686
• Publication Date: 2022-03-31T00:44:30Z
• Authors: Peiyuan Wang; Yaling Huang; Jierui Jing; Fen Wang; Xingwei Li
• Keywords: Atropisomer; Annulation

Reported herein is the efficient and atroposelective construction of two categories C-N atropisomers via rhodium(III)-catalyzed C-H activation sulfoxonium ylides en route to [4+2] annulation with sterically hindered, electron-rich alkynes. This reaction proceeds high regio- enantioselectivity under redox-neutral conditions a double-substrate strategy, providing novel entry axially chiral 4-functionalized 1-naphthols.