Electrochemically Promoted [3 + 2] Annulation of Imidazo[1,2-a]pyridine with Alkynes

• DOI: 10.1021/acs.orglett.2c02980
• Publication Date: 2022-10-05T13:38:55Z
• Authors: Meng-Qi Ping; Ming-Zhong Guo; Rui-Tao Li; Zi-Chen Wang; Cheng Ma; Li-Rong Wen; Shao-Fei Ni; Weisi Guo; Ming Li; Lin-Bao Zhang
• Keywords: Annulation; Scope (computer science)

The efficient electrochemically promoted [3 + 2] annulation of imidazo[1,2-a]pyridines with alkynes using traceless electrons as green reagents has been developed, leading to the synthesis a large class polycyclic heteroaromatics in good yields broad substrate scope under mild and conditions. scaled-up experiment, follow-up procedures, potential biological applications show practicability feasibility electrochemical method.