Metallaphotoredox-Enabled Construction of the P(O)–N Bond from Aromatic Amines and P(O)–H Compounds

• DOI: 10.1021/acs.orglett.2c03860
• Publication Date: 2022-12-06T19:22:59Z
• Authors: Kai-Cheng Yu; Hai Li; Yuan-Hong Tu; Hui Zhao; Xiang-Guo Hu
• Keywords: Scope (computer science); Electrophilic aromatic substitution; Dual role

We have developed a dual copper/photoredox-catalyzed approach for the construction of P(O)-N bond from commercially available aromatic amines and P(O)-H compounds. This metallaphotoredox method avoids toxic or corrosive reagents does not require prefunctionalized substrates. The reaction has broad substrate scope is suitable synthesis phosphonamides phosphinamides, thus complementing previous nonphotochemical approaches. amenable to direct modification drug molecules can be conducted on gram scale.