Electrochemical Isothiocyanation of Primary Amines

• DOI: 10.1021/acs.orglett.3c00128
• Publication Date: 2023-02-14T21:33:57Z
• Authors: Cyrille Kiaku; Jamie M. Walsh; Matthew C. Leech; Darren L. Poole; Joseph Mason; Iain C. A. Goodall; Perry Devo; Kevin Lam
• Keywords: 01 natural sciences; 3. Good health; 0104 chemical sciences

Isothiocyanates are ubiquitous building blocks used across the fields. Nevertheless, their classical syntheses very often rely on the use of toxic and expensive reagents. Herein, we report a new practical, mild, high-yielding, and supporting-electrolyte-free electrochemical method for the preparation of aliphatic and aromatic isothiocyanates from amine and carbon disulfide.