Nitrogen Atom Transfer Enables the (5+1) Annulation Reaction to Access Aminoisoquinolines

• DOI: 10.1021/acs.orglett.3c01258
• Publication Date: 2023-06-05T12:27:11Z
• Authors: Gayyur; Shivani Choudhary; Ruchir Kant; Nayan Ghosh
• Keywords: Annulation; Isoquinoline; Nitrogen atom; Bond cleavage; Cleavage (geology); Functional group

Herein, a catalytic synthetic transformation offering series of -NH2 group-bearing aminoisoquinolines with moderate to good yields has been showcased. Interestingly, the nitrogen atom isoquinoline ring is coming from reaction medium upon metal-assisted C≡N bond cleavage. Moreover, this (5+1) annulation shows broad substrate variation. Furthermore, derivatization core via functional group interconversions and mechanistic studies identify intermediate have carried out successfully.