Visible-Light-Induced Stoichiometric Coupling of Alkylarenes and Trifluoromethyl Ketones

• DOI: 10.1021/acs.orglett.3c01307
• Publication Date: 2023-05-17T15:56:51Z
• Authors: Qiao-Lin Wang; Huawen Huang; Mengqi Zhu; Tianci Xu; Guojiang Mao; Guo-Jun Deng
• Keywords: Oxidizing agent; Stoichiometry; Primary (astronomy); Surface Modification

A visible-light induced direct C(sp3)-H functionalization of alkylarenes with trifluoromethyl ketones has been reported to access valuable benzyl-substituted alcohols in a stoichiometric manner. Readily available petroleum-derived are employed as latent benzylation reagents. With bromine radical the hydrogen atom transfer reagent, primary, secondary, and tertiary benzyl C–H bonds suitable coupling partners. Additionally, late-stage modification bioactive molecules highlights potential application this approach.