Photoredox-Catalyzed Three-Component Amidoheteroarylation of Unactivated Alkenes

• DOI: 10.1021/acs.orglett.3c01376
• Publication Date: 2023-05-30T20:07:52Z
• Authors: Mengxuan Zhang; Ji Zhang; Yuchen Zhou; Yuxuan He; Jie Wu; Danqing Zheng
• Keywords: Quinoxaline; Hydroxylamine; Photoredox catalysis; Component (thermodynamics)

A photoredox-catalyzed 1,2-amidoheteroarylation of unactivated alkenes with O-acyl hydroxylamine derivatives and heterocycles is presented. range heterocycles, including quinoxaline-2(1H)-ones, azauracils, chromones, quinolones, are capable for this process, allowing the direct synthesis valuable heteroarylethylamine derivatives. Structurally diverse reaction substrates, drug-based scaffolds, were successfully applied, demonstrating practicality method.