Ir-Catalyzed Ortho-Selective C–H Borylation of Difluoromethyl Arenes

• DOI: 10.1021/acs.orglett.3c02308
• Publication Date: 2023-10-02T13:36:16Z
• Authors: Chen-Yuan Li; Zengyu Zhang; Xiaoyu Yan
• Keywords: Borylation

The difluoromethyl group (CF2H) has received great attention due to its distinct properties in recent years. Herein, we report a new strategy for postmodification of compounds. Ortho-selective C-H borylation arenes is achieved by cyclometalated mesoionic carbene-Ir complex. regioselectivity controlled hydrogen bond between CF2H and the boryl via outer-sphere direction.