Dysambiol, an Anti-inflammatory Secomeroterpenoid from a Dysidea sp. Marine Sponge

• DOI: 10.1021/acs.orglett.3c02409
• Publication Date: 2023-08-23T11:44:02Z
• Authors: Wei-Hua Jiao; Jia-Xin Li; Hong-Yan Liu; Xiang-Chao Luo; Tian-Yong Hu; Guo-Hua Shi; Dong-Dong Xie; Hai-Feng Chen; Bao-Hui Cheng; Hou-Wen Lin
• Keywords: Sponge

An unusual secomeroterpenoid, dysambiol (1), was isolated from a Dysidea sp. marine sponge collected the South China Sea. Dysambiol features an unprecedented secomeroterpene scaffold with rare lactone bridge. The structure of 1 determined by extensive spectroscopic analysis, Mosher's method, and electronic circular dichroism calculation. displayed potent anti-inflammatory activity in LPS-induced Raw 264.7 macrophages regulating NF-κB/MPAK signaling pathway.