Reductive N-Formylation of Nitroarenes Mediated by Rongalite

• DOI: 10.1021/acs.orglett.3c02839
• Publication Date: 2023-09-28T12:25:09Z
• Authors: Huai-Yu Wang; Xiang-Long Chen; Chun-Yan Wu; Dong-Sheng Yang; Ting Chen; An-Xin Wu
• Keywords: Formylation

Herein, we disclose a straightforward approach to access transition-metal-free reductive N-formylation of nitroarenes. This reaction integrates the dual role rongalite, which acts as reductant and C1 building block concurrently. provides an alternative method for synthesis N-aryl formamides from nitroarenes, including construction C–N bond. The utility this protocol was demonstrated by scale-up late-stage functionalizations complex molecules.