Catalytic π–π Interactions Triggered Photoinduced Synthesis of Biaryls

• DOI: 10.1021/acs.orglett.3c03806
• Publication Date: 2024-01-03T14:21:30Z
• Authors: Vishal Jyoti Roy; Janardan Chakraborty; Sudipta Raha Roy
• Keywords: Alkyne; Surface Modification; Functional group

A highly regioselective photocatalytic method to access a variety of biaryl motifs under metal-free conditions has been developed. The organophotocatalyst is involved in π–π stacking interactions with the alkyne species, which promotes this process thiophene. Mechanistic studies have shed light on these and overall process. Along broad functional-group tolerance excellent regioselectivity, protocol utilized late-stage functionalization pharmaceuticals other natural products.