Regioselective Twofold Annulation of Propargyl Acetates

• DOI: 10.1021/acs.orglett.4c00834
• Publication Date: 2024-04-02T16:54:34Z
• Authors: Manoj Sethi; Shubham Dutta; Akhila K. Sahoo
• Keywords: Annulation; Propargyl

The regioselective annulation of unsymmetrical alkynes has always been a focused research topic. A Pd-catalyzed double (i.e., yne-acetates) with aryl diazonium salts for the synthesis substituted naphthalene derivatives is developed. process addresses intrinsic regioselectivity challenges in annulations alkynes. Mechanistic investigations shed light on crucial role acetate-directing groups determining regiochemical reaction outcome.