Genome Mining of a Deep-Sea-Derived Penicillium allii-sativi Revealed Polyketide-Terpenoid Hybrids with Antiosteoporosis Activity

• DOI: 10.1021/acs.orglett.4c01065
• Publication Date: 2024-04-26T14:37:38Z
• Authors: Chun-Lan Xie; Tai-Zong Wu; Yuan Wang; Robert J. Capon; Ren Xu; Xian-Wen Yang
• Keywords: Carbon skeleton; Quantum chemical

Two novel meroterpenoids, alliisativins A and B (1, 2) were discovered through a genome-based exploration of the biosynthetic gene clusters deep-sea-derived fungus Penicillium allii-sativi MCCC entry 3A00580. Extensive spectroscopic analysis, quantum calculations, chemical derivatization, biogenetic considerations utilized to establish their structures. Alliisativins possess unique carbon skeleton featuring drimane sesquiterpene with highly oxidized polyketide. Noteworthily, alliisativin (1) showed dual activity in promoting osteogenesis inhibiting osteoclast, indicating an antiosteoporosis potential.