Alkyl Sulfonium Salts Enabled Radical Thiocyanohydroxylation of Alkenes

• DOI: 10.1021/acs.orglett.4c03554
• Publication Date: 2024-10-30T15:53:59Z
• Authors: Minghan Wang; Yanhu Wang; Chenglong Zhang; Liang Zhang
• Keywords: Sulfonium; Radical ion

Herein, we report a novel and practical strategy for alkyl sulfonium salts mediating radical thiocyanohydroxylation of alkenes. This reaction features metal-free mild conditions, generation noncarbon radicals from the readily available salts, easy handling, excellent functional group compatibility. A diverse range activated unactivated alkenes worked well to deliver various β-thiocyanato alcohols.