Photoredox/Iron Dual-Catalysis-Enabled [4 + 2] Cyclization of Acyl Nitrene with Alkynes

• DOI: 10.1021/acs.orglett.4c04069
• Publication Date: 2024-12-13T12:02:52Z
• Authors: Shimin Xie; Shuwang Tang; Ming Hou; Wenlin Xie; Meng Guan; Tianwen Bai; Linli He; Guanyinsheng Qiu
• Keywords: Nitrene; Dual role

In this work, the annulation of acyl nitrene with alkynes is reported under photoredox/iron dual-catalysis for synthesis a series isoquninalin-2-ones. The reaction featured high regioselectivity and good generality. particular, resulting isoquinalin-2-ones could be structurally elaborated into several biologically interesting scaffolds. Mechanism investigation suggests that was ascribed to formal [4 + 2] cyclization. It believed represents an initial example preparing isoquinolin-1-ones from ferric peroxyl-catalyzed insertion.