Remote C(sp3)–H Carboxylation with CO2 via Visible-Light-Catalyzed 1,5-Hydrogen Atom Transfer

• DOI: 10.1021/acs.orglett.4c04294
• Publication Date: 2024-12-13T08:16:44Z
• Authors: Haoran Huang; Xiaoyu Lin; Fanyuanhang Yang; Yuxi Ren; Yuzhen Gao; Weiping Su
• Keywords: Carboxylation; Hydrogen atom; Visible spectrum; Carbon atom

The direct carboxylation of C(sp3)–H bonds with CO2 represents a challenging but highly attractive strategy in organic synthesis. In this study, we presented visible-light-catalyzed for carboxylating remote via aryl radical induced 1,5-hydrogen atom transfer. This transformation involves generating alkyl radicals transfer from radicals, forming carbanions as key intermediates, and subsequent nucleophilic attack CO2, thereby enabling access to variety tertiary quaternary carboxylic acids moderate good yields.