Allylic Acetal as 3C Synthon in Rh(III)-Catalyzed Divergent C–H Activation/[4 + 3] Annulation: Easy Access to Benzodiazepines

• DOI: 10.1021/acs.orglett.4c04396
• Publication Date: 2025-04-02T07:31:21Z
• Authors: Mingming Hu; Chao Pi; Yangjie Wu; Xiuling Cui
• Keywords: Synthon; Annulation

A concise synthesis of benzodiazepines via Rh(III) catalyzed C-H activation/ [4 + 3] annulation easily available 1-arylpyrazolidinones with allylic acetal has been developed. The was employed as a novel 3C synthon in this transformation. Benzodiazepines were built under mild reaction conditions high efficiency and chemoselectivity. atom-economy accessible substrates reveal potential application.